Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo
. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells. Myristoylated version of L803
(Cat. No. 2235).
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Sold under licence from Tel Aviv University Future Technology LP.
Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death.
Chen et al.
FASEB J., 2004;18:1162
Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus.
Kaidanovich-Beilin et al.
Insulin mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3.
Plotkin et al.
The citations listed below are publications that use Tocris products. Selected citations for L803-mts include:
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