Discontinued Product

2256 has been discontinued.
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GSK-3 Inhibitors Peptide
1 Image
Description: Selective inhibitor of GSK-3
Product Details
Citations (1)

Biological Activity

Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.

Technical Data


(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)

Soluble to 1 mg/ml in 20% acetonitrile / water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under licence from Tel Aviv University Future Technology LP.

Background References

  1. Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxyDA-induced neuronal death.
    Chen et al.
    FASEB J., 2004;18:1162
  2. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus.
    Kaidanovich-Beilin et al.
    Biol.Psychiatry, 2004;55:781
  3. Ins mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3.
    Plotkin et al.
    J.Pharm.Exp.Ther., 2003;305:974

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for L803-mts

The citations listed below are publications that use Tocris products. Selected citations for L803-mts include:

1 Citation: Showing 1 - 1


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