L803-mts

Discontinued Product

2256 has been discontinued.
Cat.No. 2256 - L803-mts | Myr-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-pSer-Pro-NH2  | CAS No. 1043881-55-5
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Description: Selective inhibitor of GSK-3
Product Details
Citations (1)
Reviews

Biological Activity

Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.

Technical Data

M.Wt:
1464.64
Formula:
C66H110N15O20P
Sequence:
GKEAPPAPPQSP

(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)

Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Store at -20°C
CAS No:
1043881-55-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under licence from Tel Aviv University Future Technology LP.

Background References

  1. Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death.
    Chen et al.
    FASEB J., 2004;18:1162
  2. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus.
    Kaidanovich-Beilin et al.
    Biol.Psychiatry, 2004;55:781
  3. Insulin mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3.
    Plotkin et al.
    J.Pharm.Exp.Ther., 2003;305:974

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Citation for L803-mts

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