Biological ActivitySelective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.
(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxyDA-induced neuronal death.
Chen et al.
FASEB J., 2004;18:1162
Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus.
Kaidanovich-Beilin et al.
Ins mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3.
Plotkin et al.
Citation for L803-mts
The citations listed below are publications that use Tocris products. Selected citations for L803-mts include:
1 Citation: Showing 1 - 1
Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.
Authors: Hill Et al.
Int J Obes (Lond) 2015;45:1103
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