Key Product Details

Species Reactivity

Human

Applications

Western Blot, Neutralization, Immunocytochemistry

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Polyclonal Goat IgG
View all LAP (TGF-beta 1) Primary Antibodies »

Product Specifications

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived and Chinese hamster ovary cell line CHO-derived recombinant human LAP TGF‑ beta 1
Leu30-Ser390
Accession # P01137

Specificity

Detects human LAP TGF‑ beta 1 in direct ELISAs and Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for LAP (TGF-beta 1) Antibody [FITC]

Application
Recommended Usage

Immunocytochemistry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Neutralization

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: LAP (TGF-beta 1)

TGF-beta 1 is expressed as a proprotein that is cleaved within the trans-Golgi to yield a latency-associated peptide (LAP) and the mature TGF-beta 1. Disulfide-linked homodimers of LAP and TGF-beta 1 remain noncovalently associated after secretion, forming the small latent TGF-beta 1 complex. Purified LAP can also associate with active TGF-beta and neutralize TGF-beta activity. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that can interact with the extracellular matrix. TGF-beta activation from latency is controlled by multiple factors including Plasmin, MMP-9, Thrombospondin-1, and various Integrins. The TGF-beta 1 LAP is capable of complexing with and inactivating all other human TGF-beta isoforms and those of most other species.

Long Name

Latency-associated Peptide

Alternate Names

LAP (TGFbeta 1)

Gene Symbol

TGFB1

Additional LAP (TGF-beta 1) Products

Product Documents for LAP (TGF-beta 1) Antibody [FITC]

Certificate of Analysis

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Download SDS

Product Specific Notices for LAP (TGF-beta 1) Antibody [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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