Catalog Number: 6151
Chemical Name: 5-(6-(4-(1-Piperazinyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Biological Activity
Potent ALK inhibitor (IC50 values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Exhibits selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Inhibits heterotopic ossification in a mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC50 values < 100 nM).
Technical Data
  • M.Wt:
    406.48
  • Formula:
    C25H22N6
  • Solubility:
    Soluble to 50 mM in 2eq.HCl
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1432597-26-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patent 14/776,302
Background References
  1. Development of an ALK2-biased BMP type I receptor kinase inhibitor.
    Mohedas et al.
    ACS Chem.Biol., 2013;8:1291
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