Retinoic acid antagonist; displays moderate selectivity for RARβ
�values are 0.22 and 1.4 μ
M respectively). Highly selective over RARγ
. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50
= 150 nM).
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All Tocris products are intended for laboratory research use only.
Retinobenzoic acids. 6. Retinoid antagonists with heterocyclic ring.
Eyrolles et al.
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
Umemiya et al.
Identification of a novel class of retinoic acid receptor β-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.
Li et al.
The citations listed below are publications that use Tocris products. Selected citations for LE 135 include:
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