LE 135

Key Product Details

Product Description

LE 135 is a retinoic acid antagonist; displays moderate selectivity for RARβ over RARα (K_i values are 0.22 and 1.4 μM respectively). Highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC₅₀ = 150 nM).

Product Specifications for LE 135

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LE 135

The following data is based on the product molecular weight 438.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.80 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 447 publications citing the usage of this product.

• Umemiya Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J.Med.Chem. 1997 PMID: 9435893
• Li Identification of a novel class of retinoic acid receptor β-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J.Biol.Chem. 1999 PMID: 10336422
• Eyrolles Retinobenzoic acids. 6. Retinoid antagonists with heterocyclic ring. J.Med.Chem. 1994 PMID: 8182710

Product Documents for LE 135