LE 135

Catalog # Availability Size / Price Qty
2021/10
2021/50
Cat.No. 2021 - LE 135 | C29H30N2O2 | CAS No. 155877-83-1
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Description: Selective RARβ antagonist

Chemical Name: 4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid

Purity: ≥97%

Product Details
Citations (14)
Reviews

Biological Activity

Retinoic acid antagonist; displays moderate selectivity for RARβ over RARα (Ki values are 0.22 and 1.4 μM respectively). Highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM).

Technical Data

M.Wt:
438.56
Formula:
C29H30N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
155877-83-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for LE 135

The citations listed below are publications that use Tocris products. Selected citations for LE 135 include:

14 Citations: Showing 1 - 10

  1. Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury
    Authors: Duprey-Díaz Et al.
    PLoS One  2016;11:e0162626
  2. The Expression of Bone Morphogenetic Protein 2 and Matrix Metalloproteinase 2 through Retinoic Acid Receptor Beta Induced by All-Trans Retinoic Acid in Cultured ARPE-19 Cells.
    Authors: Gao Et al.
    PLoS One  2016;11:e0150831
  3. Eosinophils from Murine Lamina Propria Induce Differentiation of Naïve T Cells into Regulatory T Cells via TGF-β1 and Retinoic Acid.
    Authors: Chen Et al.
    Dev Biol  2015;10:e0142881
  4. Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines.
    Authors: Müller Et al.
    PLoS One  2015;10:e0131467
  5. Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
    Authors: Thomas and Henry
    Cancer Res  2014;386:291
  6. All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.
    Authors: Bhatt Et al.
    J Immunol  2014;192:5098
  7. The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β.
    Authors: Gloudemans Et al.
    PLoS One  2013;8:e59822
  8. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses.
    Authors: Cruz Et al.
    PLoS Negl Trop Dis  2013;7:e2073
  9. Retinoic acid induces blood-brain barrier development.
    Authors: Mizee Et al.
    J Neurosci  2013;33:1660
  10. Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression.
    Authors: Dhandapani Et al.
    Pharmacol Res Perspect  2011;71:5245

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