LE 135

  ( 14 citations )    
Product Datasheet
Catalog Number:2021
Chemical Name:4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid
Product Details
Citations (14)
Biological Activity
Retinoic acid antagonist; displays moderate selectivity for RARβ over RARα (Ki values are 0.22 and 1.4 μM respectively). Highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for LE 135 include:

14 Citations: Showing 1 - 10
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  1. Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury
    Authors: Duprey-Díaz Et al.
    PLoS One  2016;11:e0162626
  2. The Expression of Bone Morphogenetic Protein 2 and Matrix Metalloproteinase 2 through Retinoic Acid Receptor Beta Induced by All-Trans Retinoic Acid in Cultured ARPE-19 Cells.
    Authors: Gao Et al.
    PLoS One  2016;11:e0150831
  3. Eosinophils from Murine Lamina Propria Induce Differentiation of Naïve T Cells into Regulatory T Cells via TGF-β1 and Retinoic Acid.
    Authors: Chen Et al.
    Dev Biol  2015;10:e0142881
  4. Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines.
    Authors: Müller Et al.
    PLoS One  2015;10:e0131467
  5. Retinoic acid regulation by CYP26 in vertebrate lens regeneration.
    Authors: Thomas and Henry
    Cancer Res  2014;386:291
  6. All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.
    Authors: Bhatt Et al.
    J Immunol  2014;192:5098
  7. The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β.
    Authors: Gloudemans Et al.
    PLoS One  2013;8:e59822
  8. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses.
    Authors: Cruz Et al.
    PLoS Negl Trop Dis  2013;7:e2073
  9. Retinoic acid induces blood-brain barrier development.
    Authors: Mizee Et al.
    J Neurosci  2013;33:1660
  10. Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression.
    Authors: Dhandapani Et al.
    Pharmacol Res Perspect  2011;71:5245
  11. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
    Authors: DePaolo Et al.
    Nature  2011;471:220
  12. Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid.
    Authors: Feng Et al.
    J Immunol  2010;185:5915
  13. Retinoids regulate human amniotic tissue-type plasminogen activator gene by a two-step mechanism.
    Authors: Borel Et al.
    J Cell Mol Med  2010;14:1793
  14. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
    Authors: Sun Et al.
    J Exp Med  2007;204:1775
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