LE 300

  ( 2 citations )    
Product Datasheet
Catalog Number:1674
Chemical Name:6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f][3]benzazecine
Product Details
Citations (2)
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Biological Activity
Potent and selective dopamine D1 receptor antagonist (Ki values are 0.08 - 1.9 nM and 6 - 45 nM for D1 and D2 receptors respectively). Also displays moderate affinity for the 5-HT2A receptor (Ki = 20 nM). Active in vivo.
Technical Data
  • M.Wt:
    290.41
  • Formula:
    C20H22N2
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    274694-98-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for LE 300 include:

2 Citations: Showing 1 - 2
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  1. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
    Authors: Cilz Et al.
    Cereb Cortex  2014;24:3195
  2. Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.
    Authors: Gildea Et al.
    Hypertension  2012;60:396

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