Chemical Name: 6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine
Biological ActivityLE 300 is a potent and selective dopamine D1 receptor antagonist (Ki values are 0.08 - 1.9 nM and 6 - 45 nM for D1 and D2 receptors respectively). Also displays moderate affinity for the 5-HT2A receptor (Ki = 20 nM). Active in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
DA/serotonin receptor ligands: Part IV : Synthesis and pharmacology of novel 3-benzazecines and 3-benzazonines as potential 5-HT2A and DA receptor ligands.
El-Subbagh et al.
Arch.Pharm. (Weinheim)., 2002;9:443
Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a novel type of a nanomolar DA receptor antagonist.
Kassack et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2002;366:543
7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for DA receptor antagonists.
Witt et al.
Citations for LE 300
The citations listed below are publications that use Tocris products. Selected citations for LE 300 include:
2 Citations: Showing 1 - 2
DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
Authors: Cilz Et al.
Cereb Cortex 2014;24:3195
DA and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells.
Authors: Gildea Et al.
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