Chemical Name: N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
Biological ActivityOxazolidinone antibiotic. Inhibits bacterial protein synthesis prior to chain initiation. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo. Identified as targeting human host cell proteins that interact with SARS-CoV-2.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multi-drug-resistant gram-positive bacterial infections.
Brickner et al.
In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections.
Ford et al.
Antimicrob.Agents Chemother., 1996;40:1508
Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.
Brickner et al.
A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing.
Gordon et al.
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Reviews for Linezolid
Average Rating: 4.5 (Based on 2 Reviews)
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Used Linezolid to identify its effectivenes against MRSA infections caused by hospitalization.
Linezolid was used in resistance studies. Antibiotic susceptibility testing was done for each isolate by the Kirby-Bauer disc diffusion method (DDM). The antibiotic works ideally and would use again.