Chemical Name: N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
Biological ActivityLinezolid is an oxazolidinone antibiotic. Inhibits bacterial protein synthesis prior to chain initiation. Displays potent antibacterial activity against a variety of multidrug-resistant gram-positive microbes in vitro and in vivo. Identified as targeting human host cell proteins that interact with SARS-CoV-2.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multi-drug-resistant gram-positive bacterial infections.
Brickner et al.
In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections.
Ford et al.
Antimicrob.Agents Chemother., 1996;40:1508
Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.
Brickner et al.
A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing.
Gordon et al.
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Reviews for Linezolid
Average Rating: 4.5 (Based on 2 Reviews)
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Used Linezolid to identify its effectivenes against MRSA infections caused by hospitalization.
Linezolid was used in resistance studies. Antibiotic susceptibility testing was done for each isolate by the Kirby-Bauer disc diffusion method (DDM). The antibiotic works ideally and would use again.