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LP 12 hydrochloride

Catalog #: 2925 Datasheet / COA / SDS

Discontinued Product

2925 has been discontinued.
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LP 12 hydrochloride | CAS No. 1185136-22-4 | 5-HT7 Receptor Agonists
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Description: 5-HT7 agonist

Chemical Name: 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide hydrochloride

Purity: ≥99%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.22, 7.3, 52.7 and 326 nM respectively). Induces relaxation of substance P-induced contractions in guinea pig ileum (EC50 = 1.77 μM).

Technical Data

M.Wt:
518.13
Formula:
C32H39N3O.HCl
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1185136-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Bari

Background References

  1. Serotonin is a key factor for mouse red blood cell survival.
    Amireault P, Bayard E, Launay J, Sibon D, Le Van Kim C, Colin Y, Dy M, Hermine O, Cote F
    PLoS ONE, 2013;8(12):e83010.
  2. Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents.
    Leopoldo et al.
    J.Med.Chem., 2007;50:4214

Product Datasheets

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