Ligand of the 5-HT7
= 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1
values are 156 and 476 nM respectively).
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Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo.
Lacivita et al.