LP 44

  ( 2 citations )    
Product Datasheet
Catalog Number:2534
Chemical Name:4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride
Product Details
Citations (2)
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Biological Activity
High affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
Technical Data
  • M.Wt:
    488.13
  • Formula:
    C27H37N3OS.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    824958-12-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the University of Bari
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for LP 44 include:

2 Citations: Showing 1 - 2
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  1. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Mol Med  2015;3:e00103
  2. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
    Authors: Murray Et al.
    J Neurophysiol  2011;106:925

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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human 5-HT7 (NP_000863) VersaClone cDNA

RDC0251
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Human 5-HT7 (NP_062874) VersaClone cDNA

RDC0252
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