High affinity 5-HT7
receptor agonist (Ki
= 0.22 nM) that displays selectivity over 5-HT1A
receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50
= 2.56 μ
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Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
Leopoldo et al.
The citations listed below are publications that use Tocris products. Selected citations for LP 44 include:
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