Catalog Number: 2534
Chemical Name: 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride
Biological Activity
High affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
Technical Data
  • M.Wt:
    488.13
  • Formula:
    C27H37N3OS.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    824958-12-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the University of Bari
Background References
  1. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo et al.
    J.Med.Chem., 2004;47:6616
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LP 44 include:

1 Citations: Showing 1 - 1

  1. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Mol Med 2015;3:e00103

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