LRP-6 Antibody (C7) - BSA Free

Novus Biologicals | Catalog # NBP3-41920

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Porcine

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # C7

Format

BSA Free
View all LRP-6 Primary Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Human LRP-6 (Uniprot#: O75581; Trp981-Gly1213 (Uniprot#: O75581)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for LRP-6 Antibody (C7) - BSA Free

LRP-6 Antibody (C7)

Immunohistochemistry-Paraffin: LRP-6 Antibody (C7) [NBP3-41920] -

Immunohistochemistry-Paraffin: LRP-6 Antibody (C7) [NBP3-41920] - DAB staining on IHC-P; Sample: Human Liver Tissue; Primary Ab: 20ug/ml NBP3-41920; Second Ab: 2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody

Applications for LRP-6 Antibody (C7) - BSA Free

Application
Recommended Usage

Immunohistochemistry

5-20ug/mL

Immunohistochemistry-Paraffin

5-20ug/mL

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.01M PBS, pH7.4, 50% glycerol

Format

BSA Free

Preservative

0.05% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: LRP-6

Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot (see Application Notes below). However no additional claims are made for their ability to recognise native protein in any application. LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

Long Name

LDL Receptor-related Protein 6

Alternate Names

ADCAD2, FLJ90062, FLJ90421, LRP6

Gene Symbol

LRP6

Additional LRP-6 Products

Product Documents for LRP-6 Antibody (C7) - BSA Free

Certificate of Analysis

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Product Specific Notices for LRP-6 Antibody (C7) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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