Partial agonist of hydroxycarboxylic acid receptor 2 (HCA2
= 0.55 μ
M). Thought to lower plasma very-low-density lipoprotein (VLDL)-triglyceride levels by affecting hepatic VLDL production in normolipidemic C57BL/6 mice.
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Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice.
Li et al.