Chemical Name: 5-Butyl-1H-pyrazole-3-carboxylic acid
Biological ActivityLUF 6283 is a partial agonist of hydroxycarboxylic acid receptor 2 (HCA2) (Ki = 0.55 μM). Thought to lower plasma very-low-density lipoprotein (VLDL)-triglyceride levels by affecting hepatic VLDL production in normolipidemic C57BL/6 mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of pyrazole partial agonists on HCA2-mediated flushing and VLDL-triglyceride levels in mice.
Li et al.
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