Catalog Number: 1521
Chemical Name: (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid
Biological Activity
Competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.
Technical Data
  • M.Wt:
    211.22
  • Formula:
    C8H13N5O2
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    125546-04-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Background References
  1. Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action.
    Schoepp et al.
    J.Pharmacol.Exp.Ther., 1990;255:1301
  2. Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia.
    Madden et al.
    J.Neurosurg., 1992;76:106
  3. Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate antagonists in rabbits.
    Madden et al.
    Stroke, 1993;24:1068

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