Chemical Name: (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid
Biological ActivityLY 233053 is a competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-MthD.-aspartic acid antagonist with a short duration of action.
Schoepp et al.
Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia.
Madden et al.
Delayed therapy of experimental ischemia with competitive N-MthD.-aspartate antagonists in rabbits.
Madden et al.
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