Selective secreted phospholipase A2
) inhibitor (IC50
values are <1 μ
M for group IIA and <50 μ
M for group V). Attenuates VEGF-mediated platelet-activating factor (PAF) synthesis in BAEC and HUVEC cells at a concentration of 100 μ
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Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2.
Schevitz et al.
VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2.
Bernatchez et al.
High-affinity aptamers selectively inhibit human nonpancreatic secretory phospholipase A2 (hnps-PLA2).
Bridonneau et al.
The citations listed below are publications that use Tocris products. Selected citations for LY 311727 include:
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