LY 333531 hydrochloride

Catalog # Availability Size / Price Qty
4738/1
Cat.No. 4738 - LY 333531 hydrochloride | C28H28N4O3.HCl | CAS No. 169939-93-9
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Description: Protein kinase C inhibitor; selective for β isozymes
Alternative Names: Ruboxistaurin

Chemical Name: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride

Product Details
Citations (2)
Reviews

Biological Activity

Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).

Technical Data

M.Wt:
505.01
Formula:
C28H28N4O3.HCl
Solubility:
Soluble to 20 mM in DMSO
Storage:
Store at -20°C
CAS No:
169939-93-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selec
    Jirousek et al.
    J.Med.Chem., 1996;39:2664
  2. Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ.
    Faul et al.
    Bioorg.Med.Chem.Lett., 2003;13:1857
  3. Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets.
    Samokhin et al.
    Eur.J.Pharmacol., 1999;386:297
  4. Synthesis and Characterization of the Selective, Reversible PKC� Inhibitor (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, Ruboxistaurin (LY333531)
    Lewin et al.
    A.C.S.Chem.Neurosci., 2018;

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Citations for LY 333531 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for LY 333531 hydrochloride include:

2 Citations: Showing 1 - 2

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