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LY 333531 hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:4738
Alternate Names:Ruboxistaurin
Chemical Name:(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride
Product Details
Citations (2)
Reviews
Biological Activity
Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
Technical Data
  • M.Wt:
    505.01
  • Formula:
    C28H28N4O3.HCl
  • Solubility:
    Soluble to 20 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    169939-93-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 333531 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells.
    Authors: Cosgrove
    Nature Materials  2016;15:1297
  2. Targeting a cell state common to triple-negative breast cancers.
    Authors: Muellner Et al.
    ASN Neuro  2015;11:789

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