Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβ
I and PKCβ
values are 4.7 and 5.9 nM respectively). Selective for PKCβ
over other PKC isozymes (IC50
values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μ
M for PKCη
respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selec
Jirousek et al.
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ.
Faul et al.
Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets.
Samokhin et al.
The citations listed below are publications that use Tocris products. Selected citations for LY 333531 hydrochloride include:
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