LY 333531 hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:4738
Alternate Names:Ruboxistaurin
Chemical Name:(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride
Product Details
Citations (2)
Reviews
Biological Activity
Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
Technical Data
  • M.Wt:
    505.01
  • Formula:
    C28H28N4O3.HCl
  • Solubility:
    Soluble to 20 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    169939-93-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 333531 hydrochloride include:

2 Citations: Showing 1 - 2
Filter your results:

  1. N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells.
    Authors: Cosgrove
    Nature Materials  2016;15:1297
  2. Targeting a cell state common to triple-negative breast cancers.
    Authors: Muellner Et al.
    ASN Neuro  2015;11:789

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used LY 333531 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee