Lys-Bradykinin
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Description: Potent bradykinin agonist (B2 > B1)
Alternative Names: Kallidin
Biological Activity
Endogenous bradykinin receptor agonist that displays some selectivity for the B2 receptor (Ki values are 2.54 and 0.63 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. Twice as potent as bradykinin (Cat No. 3004) in vivo.Technical Data
M.Wt:
1188.39
Formula:
C56H85N17O12
Sequence:
KRPPGFSPFR
Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
342-10-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Classification of kinin receptors.
Regoli et al.
Biol.Chem., 2001;382:31 -
Pharmacology of bradykinin and related kinins.
Regoli and Barabe
Pharmacol.Rev., 1980;32:1 -
International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences.
Leeb-Lundberg et al.
Pharmacol.Rev., 2005;57:27
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