Chemical Name: 4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Biological ActivityM 344 is a histone deacetylase inhibitor (IC50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.
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Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation.
Jung et al.
M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells.
Takai et al.
The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells.
Riessland et al.
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