Chemical Name: 4-Fluoro-N-methyl-L-phenylalanyl-N-methyl-L-valyl-3-(1,1-dimethylethyl)-N-ethyl-L-tyrosinamide
Biological ActivityPotent and selective, competitive motilin receptor antagonist (IC50 = 4.9 nM). Selective for the motilin receptor over a range of other receptors and ion channels. Inhibits motilin-induced duodenal muscle contractions in vitro. Also inhibits motilin-induced colonic and abdominal contractions in vivo. Orally active.
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