Selective ASIC1a inhibitor (IC50
values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Binds to closed/inactive channel. Selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2
3.2 and Kv
1.2 channels. Increases latency of withdrawal response in mouse tail-flick and paw-flick tests. Analgesic.
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All Tocris products are intended for laboratory research use only.
Black mamba venom peptides target acid-sensing ion channels to abolish pain.
Diochot et al.