Mca-KPLGL-Dpa-AR-NH2 Fluorogenic Peptide Substrate

Substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, ADAM10, ADAM17/TACE, Cathepsin D, and Cathepsin E
Catalog # Availability Size / Price Qty
ES010
Product Details
Citations (20)
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Mca-KPLGL-Dpa-AR-NH2 Fluorogenic Peptide Substrate Summary

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

ES010

Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Samples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light.
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Citations for Mca-KPLGL-Dpa-AR-NH2 Fluorogenic Peptide Substrate

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

20 Citations: Showing 1 - 10
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  1. Macrocyclic ?-defensins suppress tumor necrosis factor-? (TNF-?) shedding by inhibition of TNF-? converting enzyme
    Authors: JB Schaal, T Maretzky, DQ Tran, PA Tran, P Tongaonkar, CP Blobel, AJ Ouellette, ME Selsted
    J. Biol. Chem., 2018;0(0):.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  2. Efficient protease based purification of recombinant matrix metalloprotease-1 in E. coli
    Authors: L Kumar, W Colomb, J Czerski, CR Cox, SK Sarkar
    Protein Expr. Purif., 2018;0(0):.
    Applications: Enzyme Assay Substrate
  3. Centrosomal protein 55 activates NF-?B signalling and promotes pancreatic cancer cells aggressiveness
    Authors: T Peng, W Zhou, F Guo, HS Wu, CY Wang, L Wang, ZY Yang
    Sci Rep, 2017;7(1):5925.
    Species: Human
    Sample Types: Protein
    Applications: Enzyme Assay
  4. Fluid shear stress activates YAP1 to promote cancer cell motility
    Authors: HJ Lee, MF Diaz, KM Price, JA Ozuna, S Zhang, EM Sevick-Mur, JP Hagan, PL Wenzel
    Nat Commun, 2017;8(0):14122.
    Species: Human
    Sample Types: Cell Lysates
  5. Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour
    Open Biol, 2016;6(11):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  6. Harnessing the natural inhibitory domain to control TNF? Converting Enzyme (TACE) activity in vivo
    Sci Rep, 2016;6(0):35598.
  7. Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour
    Open Biol, 2016;6(11):.
    Species: Human
    Sample Types: Whole Cells
  8. Expanding the Activity of Tissue Inhibitors of Metalloproteinase (TIMP)-1 against Surface-Anchored Metalloproteinases by the Replacement of Its C-Terminal Domain: Implications for Anti-Cancer Effects.
    Authors: Duan J, Rapti M, Tsigkou A, Lee M
    PLoS ONE, 2015;10(8):e0136384.
  9. Sequential Amyloid-beta Degradation by the Matrix Metalloproteases MMP-2 and MMP-9.
    Authors: Hernandez-Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, Ghiso J
    J Biol Chem, 2015;290(24):15078-91.
    Species: Human
    Sample Types: Protein
    Applications: Enzyme Assay
  10. Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection.
    Authors: Zhu, Wenhan, Tao, Lili, Quick, Marsha L, Joyce, Johanna, Qu, Jie-Ming, Luo, Zhao-Qin
    PLoS Pathog, 2015;11(3):e1004704.
    Species: Mouse
    Sample Types: Whole Cells
  11. Interdomain Contacts and the Stability of Serralysin Protease from Serratia marcescens.
    Authors: Zhang L, Morrison A, Thibodeau P
    PLoS ONE, 2015;10(9):e0138419.
    Species: Bacteria - Serratia marcescens
    Sample Types: Protein
  12. ADAM17-mediated shedding of FcgammaRIIIA on human NK cells: identification of the cleavage site and relationship with activation.
    Authors: Lajoie L, Congy-Jolivet N, Bolzec A, Gouilleux-Gruart V, Sicard E, Sung H, Peiretti F, Moreau T, Vie H, Clemenceau B, Thibault G
    J Immunol, 2014;192(2):741-51.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  13. Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors.
    Authors: Butterworth, Michael, Zhang, Liang, Liu, Xiaoning, Shanks, Robert M, Thibodeau, Patrick
    PLoS ONE, 2014;9(6):e100313.
    Species: Bacteria - Pseudomonas aeruginosa
    Sample Types: Protein
    Applications: Bioassay
  14. Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine.
    Authors: Hayes C, Dey D, Palavicini J, Wang H, Patkar K, Minond D, Nefzi A, Lakshmana M
    BMC Med, 2013;11(0):81.
    Species: Hamster
    Sample Types: Whole Cells
  15. Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis.
    Authors: Ingvarsen S, Porse A, Erpicum C, Maertens L, Jurgensen H, Madsen D, Melander M, Gardsvoll H, Hoyer-Hansen G, Noel A, Holmbeck K, Engelholm L, Behrendt N
    J Biol Chem, 2013;288(15):10195-204.
    Species: Mouse
    Sample Types: Protein
    Applications: Enzyme Assay
  16. Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer.
    Authors: Fujisawa T, Rubin B, Suzuki A, Patel PS, Gahl WA, Joshi BH, Puri RK
    PLoS ONE, 2012;7(4):e34437.
    Species: Human
    Sample Types: Whole Cells
  17. An orally available small imidazolium salt ameliorates inflammation and fibrosis in a murine model of cholestasis.
    Authors: Ding Z, Kng Y, Yang H, Ke Z, Zhuo L
    Lab. Invest., 2011;91(5):752-63.
    Species: Mouse
    Sample Types: Tissue Homogenates
  18. Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
    Authors: Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C, Ludwig A
    Blood, 2009;113(19):4799-809.
    Species: Mouse
    Sample Types: Cell Lysates
  19. Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor.
    Authors: Yamashita Y, Kawashima I, Yanai Y, Nishibori M, Richards JS, Shimada M
    Endocrinology, 2007;148(12):6164-75.
    Species: Porcine
    Sample Types: Cell Lysates
  20. The shedding activity of ADAM17 is sequestered in lipid rafts.
    Authors: Tellier E, Rebsomen L
    Exp. Cell Res., 2006;312(20):3969-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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