Chemical Name: ±-N,α,-Dimethyl-3,4-methylenedioxyphenethylamine hydrochloride
Biological ActivityHallucinogenic compound that inhibits 5-HT and dopamine uptake.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or DA release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphe nucleus slices.
Iravani et al.
New insights into the mechanism of action of amphetamines.
Fleckenstein et al.
MDMA ("ecstasy") suppresses the innate IFN-γ response in vivo: a critical role for the anti-inflammatory cytokine IL-10.
Boyle et al.
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Rats self-administered MDMA (0.30 mg/kg/infusion, i.v.). We then showed that, following extinction of MDMA seeking, discrete MDMA-associated cues reinstated MDMA-seeking behavior. Also, the magnitude of reinstatement was positively correlated with the level of responding during MDMA self-administration.