MED12 Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-45941

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all MED12 Primary Antibodies »

Product Specifications

Immunogen

mediator complex subunit 12. (Uniprot# Q93074)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

230 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for MED12 Antibody - BSA Free

MED12 Antibody - BSA Free

Western Blot: MED12 Antibody - BSA Free [NBP3-45941] -

Western Blot: MED12 Antibody - BSA Free [NBP3-45941] - Mouse liver tissue were subjected to SDS PAGE followed by western blot with (MED12 antibody) at dilution of 1:800

Applications for MED12 Antibody - BSA Free

Application
Recommended Usage

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% Glycerol, pH (7.3)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MED12

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. (provided by RefSeq)

Long Name

Mediator of RNA Polymerase II Transcription Subunit 12

Alternate Names

ARC240, CAGH45, FGS1, HOPA, OKS, TNRC11, TRAP230

Gene Symbol

MED12

Additional MED12 Products

Product Documents for MED12 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for MED12 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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