MEKK4 Antibody (S05-8A5)

Name: MEKK4 Antibody (S05-8A5)
Brand: Novus Biologicals
SKU: NBP3-19990
Price: 559 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-19990

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S05-8A5 expressed in HEK293

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Product Specifications

Immunogen

A synthetic peptide of human MEKK4 (Uniprot # Q9Y6R4)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

200 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for MEKK4 Antibody (S05-8A5)

Western Blot: MEKK4 Antibody (S05-8A5) [NBP3-19990]

Western Blot: MEKK4 Antibody (S05-8A5) [NBP3-19990] - Western blot detection of MEKK4 in HL-60, U251 cell lysates using NBP3-19990 (1:1000 diluted). Predicted band size: 182kDa. Observed band size: 200kDa.

Immunohistochemistry-Paraffin: MEKK4 Antibody (S05-8A5) [NBP3-19990]

Immunohistochemistry-Paraffin: MEKK4 Antibody (S05-8A5) [NBP3-19990] - Immunohistochemistry of MEKK4 in paraffin-embedded Human lung cancer tissue using NBP3-19990 at dilution 1/50

Applications for MEKK4 Antibody (S05-8A5)

Application

Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MEKK4

MEK kinase 4 (MEKK4), also known as MTK1, is a Ser/Thr protein kinase belonging to the MAP kinase kinase kinase family (1). This protein contains a protein kinase catalytic domain at the C-terminus. The N-terminal, non-kinase domain may contain a regulatory domain. MEKK4 regulates p38 and JNK, butnot ERK pathway, through the phosphorylation of the MAP2Ks MKK3 and MKK6 and MKK4 and MKK7 respectively (1-2).

Alternate Names

EC 2.7.11.25, FLJ42439, MAPKKK4yeast, homolog of, MEKK 4, mitogen-activated protein kinase kinase kinase 4

Gene Symbol

MAP3K4

Additional MEKK4 Products

Product Documents for MEKK4 Antibody (S05-8A5)

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Certificate of Analysis

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Product Specific Notices for MEKK4 Antibody (S05-8A5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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