Catalog Number: 1632
Biological Activity
Potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1 (pA2 = 5.66, guinea pig ileum) and NK3 (Ki > 10 mM, guinea pig brain). Active in vivo.
Technical Data
  • M.Wt:
    1081.24
  • Formula:
    C57H68N12O10
  • Sequence:
    DYWVWWK

    (Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide)

  • Storage:
    Desiccate at -20°C
  • CAS No:
    135306-85-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors.
    Bartho et al.
    Br.J.Pharmacol., 1992;105:805
  2. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.
    Maggi et al.
    J.Pharmacol.Exp.Ther., 1991;257:1172
  3. Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK2 receptor transfected cell line.
    Subramanian et al.
    Biochem.Biophys.Res.Commun., 1994;200:1512

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