MEN 10376

Name: MEN 10376
Brand: Tocris Bioscience
SKU: 1632
Price: 353 USD

Catalog #: 1632 Datasheet / COA / SDS

Discontinued Product

1632 has been discontinued.

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Description: Potent, selective NK2 antagonist

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MEN 10376 is a potent and selective NK₂ receptor antagonist (pA₂ = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK₁ (pA₂ = 5.66, guinea pig ileum) and NK₃ (K_i > 10 mM, guinea pig brain). Active in vivo.

Technical Data

M.Wt:

1081.24

Formula:

C₅₇H₆₈N₁₂O₁₀

Sequence:

DYWVWWK

(Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide)

Storage:

Desiccate at -20°C

CAS No:

135306-85-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK₂ receptors.
Bartho et al.
Br.J.Pharmacol., 1992;105:805
In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.
Maggi et al.
J.Pharmacol.Exp.Ther., 1991;257:1172
Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK₂ receptor transfected cell line.
Subramanian et al.
Biochem.Biophys.Res.Commun., 1994;200:1512

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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