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Mephedrone hydrochloride

Catalog #: 4443 Datasheet / COA / SDS

Discontinued Product

4443 has been discontinued.
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Mephedrone hydrochloride | CAS No. 1189726-22-4 | Dopamine Transporter Inhibitors
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Description: Inhibits synaptosomal dopamine and 5-HT uptake

Chemical Name: (±)-2-Methylamino-1-(4-methylphenyl)propan-1-one hydrochloride

Purity: ≥99%

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Biological Activity

Inhibits striatal dopamine uptake and hippocampal 5-HT uptake in synaptosomes (IC50 values are 467 and 558 nM respectively). Administration causes a decrease in dopamine and 5-HT transporter function. Synthetic CNS stimulant; brain penetrant.

Technical Data

M.Wt:
213.7
Formula:
C11H15NO.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1189726-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 4-methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse.
    Hadlock et al.
    J.Pharmacol.Exp.Ther., 2011;339:530

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