Catalog Number: 0568
Chemical Name: 1-(1-(3-Isothiocyanato)phenyl)cyclohexylpiperidine
Biological Activity
Acylator of PCP and σ-receptors.
Technical Data
  • M.Wt:
    300.46
  • Formula:
    C18H24N2S
  • Solubility:
    Soluble to 20 mM in ethanol with gentle warming and to 20 mM in DMSO with gentle warming
  • Storage:
    Desiccate at -20°C
  • CAS No:
    96316-00-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice.
    Debler et al.
    Eur.J.Pharmacol., 1989;165:155
  2. Metaphit, an acylating ligand for phencyclidine receptors: characterization of in vivo actions in the rat.
    Contreras et al.
    J.Pharmacol.Exp.Ther., 1986;238:1101
  3. Effect of metaphit on dopaminergic neurotransmission in rat striatal slices: involvement of the dopamine transporter and voltage-dependent sodium channel.
    Reith et al.
    J.Pharmacol.Exp.Ther., 1991;259:1188
  4. A specific acylating agent for the [3H]-phencyclidine receptors in rat brain.
    Rafferty et al.
    FEBS Lett., 1985;181:318

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