Metaphit

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice.
   Debler et al.
   Eur.J.Pharmacol., 1989;165:155
3. Metaphit, an acylating ligand for phencyclidine receptors: characterization of in vivo actions in the rat.
   Contreras et al.
   J.Pharmacol.Exp.Ther., 1986;238:1101
4. A specific acylating agent for the [³H]-phencyclidine receptors in rat brain.
   Rafferty et al.
   FEBS Lett., 1985;181:318
5. Effect of metaphit on DArgic neurotransmission in rat striatal slices: involvement of the DA transporter and voltage-dependent sodium channel.
   Reith et al.
   J.Pharmacol.Exp.Ther., 1991;259:1188

Product Datasheets