Potent antagonist for α
7-containing neuronal nicotinic receptors (Ki
= 1.4 nM). Interacts with α
2 and α
2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo
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Effects of delphinium alkaloids on neuromuscular transmission.
Dobelis et al.
Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of α7 nicotinic receptors.
Escubedo et al.
Methyllycaconitine: a selective probe for neuronal a-bungarotoxin binding sites.
Ward et al.
FEBS Lett., 1990;270:45
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