Methyllycaconitine citrate

Tocris Bioscience | Catalog # 1029

Selective α7 neuronal nAChR antagonist
Tocris Bioscience

Key Product Details

Description

Selective α7 neuronal nAChR antagonist

Alternative Names

MLA
View all Nicotinic (a7) Receptor Antagonists »

Product Description

Methyllycaconitine citrate is a potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo.

Product Specifications for Methyllycaconitine citrate

Molecular Weight

874.93

Formula

C37H50N2O10.C6H8O7

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate

CAS Number

351344-10-0

PubChem ID

90479749

InChI Key

INBLZNJHDLEWPS-IRPACCRLSA-N

SMILES

OC(=O)CC(O)(CC(O)=O)C(O)=O.[H][C@@]12C[C@H]3[C@H](OC)[C@]1([H])[C@](O)(C[C@@H]3OC)[C@]1(O)[C@@H](OC)C3[C@@]22[C@H]1N(CC)C[C@]3(COC(=O)C1=CC=CC=C1N1C(=O)C[C@H](C)C1=O)CC[C@@H]2OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 87.49 100
DMSO 87.49 100

Preparing Stock Solutions for Methyllycaconitine citrate

The following data is based on the product molecular weight 874.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.14 mL 5.71 mL 11.43 mL
5 mM 0.23 mL 1.14 mL 2.29 mL
10 mM 0.11 mL 0.57 mL 1.14 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 101 publications citing the usage of this product.

Product Documents for Methyllycaconitine citrate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Methyllycaconitine citrate

For research use only

Citations for Methyllycaconitine citrate

Customer Reviews for Methyllycaconitine citrate (1)

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  • blocking the activity of nicotinic receptor agonist
    Name: Anonymous
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 10/30/2019
    Dosed to rats as nicotininc receptor antagonist

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