Methyllycaconitine citrate

  ( 25 citations )    
Product Datasheet
Catalog Number:1029
Alternate Names:MLA
Chemical Name:[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate
Product Details
Citations (25)
Supplemental Products
Reviews
Biological Activity
Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo.
Technical Data
  • M.Wt:
    874.93
  • Formula:
    C37H50N2O10.C6H8O7
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    112825-05-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Methyllycaconitine citrate include:

25 Citations: Showing 1 - 10
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  1. Differential processing of thalamic information via distinct striatal interneuron circuits.
    Authors: Assous
    Nat Commun  2017;8:15860
  2. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature  2016;538:253
  3. Acetylcholinesterase inhibitors for Alzheimer's disease treatment ameliorate acetaminophen-induced liver injury in mice via central cholinergic system regulation
    Authors: Zhang Et al.
    the Journal of Pharmacology and Experimental Thera  2016;
  4. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    J Neurosci  2015;9:6
  5. Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine.
    Authors: Pinnock Et al.
    Arch Neurol  2015;9:30
  6. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
    Authors: Tang Et al.
    PLoS One  2015;5:14099
  7. Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.
    Authors: Brown and Wonnacott
    Sci Rep  2015;40:2047
  8. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Neurochem Res  2015;4
  9. Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.
    Authors: Dannenberg Et al.
    J Neurosci  2015;35:8394
  10. Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.
    Authors: Kiss Et al.
    PLoS One  2014;9:e109538
  11. Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor.
    Authors: Némethova Et al.
    Front Behav Neurosci  2013;8:e79264
  12. Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates.
    Authors: Callahan Et al.
    Neuropharmacology  2013;67:201
  13. Nicotine induces the up-regulation of the α7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway.
    Authors: Brown Et al.
    J Biol Chem  2013;288:33049
  14. Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.
    Authors: Yamauchi Et al.
    J Pharmacol Exp Ther  2012;82:687
  15. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.
    Authors: Leão Et al.
    Nat Neurosci  2012;15:1524
  16. Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template.
    Authors: Grimster Et al.
    J Am Chem Soc  2012;134:6732
  17. Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells.
    Authors: Lecca Et al.
    Neuropsychopharmacology  2011;36:589
  18. Regulation of glutamate release by α7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals.
    Authors: Northrop Et al.
    Am J Physiol Renal Physiol  2011;336:900
  19. Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator.
    Authors: Collins and Millar
    Mol Pharmacol  2010;78:198
  20. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  21. Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
    Authors: Li Et al.
    Auton Neurosci  2010;154:14
  22. Cortical α7 nicotinic acetylcholine receptor and β-amyloid levels in early Alzheimer disease.
    Authors: Ikonomovic Et al.
    Mol Pharmacol  2009;66:646
  23. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses.
    Authors: Li Et al.
    Neurosci Lett  2009;462:20
  24. Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells.
    Authors: Beckel Et al.
    Front Cell Neurosci  2006;290:F103
  25. Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.
    Authors: Hansen Et al.
    EMBO J  2005;24:3635
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