Mexiletine hydrochloride

  ( 2 citations )    
Product Datasheet
Catalog Number:2596
Alternate Names:Ko 1173
Chemical Name:1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride
Product Details
Citations (2)
Biological Activity
Use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets

The citations listed below are publications that use Tocris products. Selected citations for Mexiletine hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling.
    Authors: Rojas Et al.
    Front Cell Neurosci  2015;9:203
  2. Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress.
    Authors: Rojas Et al.
    Front Cell Neurosci  2014;8:24


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