Use-dependent sodium channel blocker (IC50
values are 75.3 and 23.6 μ
M for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels.
Franchini et al.
Neuroprotective effect of mexiletine in the central nervous system of diabetic rats.
Ates et al.
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.
Bellis et al.
The citations listed below are publications that use Tocris products. Selected citations for Mexiletine hydrochloride include:
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