Mexiletine hydrochloride

Key Product Details

Product Description

Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC₅₀ values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Product Specifications for Mexiletine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Mexiletine hydrochloride

The following data is based on the product molecular weight 215.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.64 mL	23.18 mL	46.36 mL
5 mM	0.93 mL	4.64 mL	9.27 mL
10 mM	0.46 mL	2.32 mL	4.64 mL
50 mM	0.09 mL	0.46 mL	0.93 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Ates Neuroprotective effect of mexil. in the central nervous system of diabetic rats. Mol.Cell.Biochem. 2006 PMID: 16541198
• Bellis Evaluation of the pharmacological activity of the major mexil. metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 2006 PMID: 16921388
• Franchini Optically active mexil. analogues as stereoselective blockers of voltage-gated Na⁺ channels. J.Med.Chem. 2003 PMID: 14613326

Product Documents for Mexiletine hydrochloride