Catalog Number: 3358
Alternate Names: Calpain inhibitor-1
Chemical Name: N-Acetyl-L-leucine-L-leucine-L-norleucinal
Biological Activity
Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
Technical Data
  • M.Wt:
    383.53
  • Formula:
    C20H37N3O4
  • Solubility:
    Soluble to 50 mM in DMSO and to 25 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    110044-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.
    Atencio et al.
    Cell Growth Differ., 2000;11:247
  2. Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat.
    Chatterjee et al.
    Kidney Int., 2001;59:2073
  3. In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.
    Sherwood et al.
    Proc.Natl.Acad.Sci.USA, 1993;90:3353
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MG 101 include:

1 Citations: Showing 1 - 1

  1. PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages
    Authors: Ishizuka Et al.
    Scientific Reports 2016;6:32092

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