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MG 101

  ( 1 citations )    
Product Datasheet
Catalog Number:3358
Alternate Names:Calpain inhibitor-1
Chemical Name:N-Acetyl-L-leucine-L-leucine-L-norleucinal
Product Details
Citations (1)
Reviews
Biological Activity
Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
Technical Data
  • M.Wt:
    383.53
  • Formula:
    C20H37N3O4
  • Solubility:
    Soluble to 50 mM in DMSO and to 25 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    110044-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MG 101 include:

1 Citations: Showing 1 - 1

  1. PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages
    Authors: Ishizuka Et al.
    Scientific Reports  2016;6:32092

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