Calpain inhibitor (IC50
= 0.09 μ
M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro
. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
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Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.
Atencio et al.
Cell Growth Differ., 2000;11:247
Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat.
Chatterjee et al.
Kidney Int., 2001;59:2073
In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.
Sherwood et al.
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