MG 101

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3358/5
MG 101 | CAS No. 110044-82-1 | Calpain Inhibitors
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Description: Calpain inhibitor; activates p53-dependent apoptosis
Alternative Names: Calpain inhibitor-1

Chemical Name: N-Acetyl-L-leucine-L-leucine-L-norleucinal

Product Details
Citations (1)
Reviews

Biological Activity

Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

Technical Data

M.Wt:
383.53
Formula:
C20H37N3O4
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Storage:
Store at -20°C
CAS No:
110044-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.
    Atencio et al.
    Cell Growth Differ., 2000;11:247
  2. Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat.
    Chatterjee et al.
    Kidney Int., 2001;59:2073
  3. In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.
    Sherwood et al.
    Proc.Natl.Acad.Sci.USA, 1993;90:3353
  4. In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1.
    Perrin et al.
    Cell Mol.Biol., 2002;48:OL267

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Citation for MG 101

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