Chemical Name: N-Acetyl-L-leucine-L-leucine-L-norleucinal
Biological ActivityCalpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.
Atencio et al.
Cell Growth Differ., 2000;11:247
Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat.
Chatterjee et al.
Kidney Int., 2001;59:2073
In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.
Sherwood et al.
In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1.
Perrin et al.
Cell Mol.Biol., 2002;48:OL267
Citation for MG 101
The citations listed below are publications that use Tocris products. Selected citations for MG 101 include:
1 Citation: Showing 1 - 1
PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages
Authors: Ishizuka Et al.
Scientific Reports 2016;6:32092
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