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MI 2 dihydrochloride

Catalog #: 4707 Datasheet / COA / SDS

Discontinued Product

4707 has been discontinued.
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MI 2 dihydrochloride | Additional Lysine Methyltransferase Compounds
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Description: Menin-MLL interaction inhibitor

Chemical Name: 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine dihydrochloride

Purity: ≥98%

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Biological Activity

Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.

Technical Data

M.Wt:
448.48
Formula:
C18H25N5S2.2HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
    Grembecka et al.
    Nat.Chem.Biol., 2012;8:277
  2. Target identification reveals lanosterol synthase as a vulnerability in glioma.
    Phillips et al.
    Proc.Natl.Acad.Sci.U.S.A., 2019;116:7957

Product Datasheets

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