Menin-MLL interaction inhibitor; binds menin (IC50
= 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.
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Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
Grembecka et al.