Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC50
values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α1
-adrenergic and 5-HT2A
serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug.
Moret et al.
Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α1-adrenergic and serotonergic 5-HT2A systems.
Maj et al.
Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation.
Suzuki et al.
The citations listed below are publications that use Tocris products. Selected citations for Milnacipran hydrochloride include:
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