Chemical Name: (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Biological ActivityOrally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α1-adrenergic and 5-HT2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug.
Moret et al.
Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α1-adrenergic and serotonergic 5-HT2A systems.
Maj et al.
Antiallodynic and antihyperalgesic effect of milnac. in mice with spinal nerve ligation.
Suzuki et al.
Citation for Milnacipran hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Milnacipran hydrochloride include:
1 Citation: Showing 1 - 1
The antinociceptive effect of milnac. in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition.
Authors: Burnham and Dickenson
J Pharmacol Exp Ther 2013;344:696
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