Catalog Number: 3286
Chemical Name: (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Biological Activity
Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α1-adrenergic and 5-HT2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.
Technical Data
  • M.Wt:
    282.81
  • Formula:
    C15H22N2O.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    101152-94-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug.
    Moret et al.
    Neuropharmacology, 1985;24:1211
  2. Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α1-adrenergic and serotonergic 5-HT2A systems.
    Maj et al.
    J.Neural.Transm., 2000;107:1345
  3. Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation.
    Suzuki et al.
    Anesth.Analg., 2008;106:1309
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Milnacipran hydrochloride include:

1 Citations: Showing 1 - 1

  1. The antinociceptive effect of milnacipran in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition.
    Authors: Burnham and Dickenson
    J Pharmacol Exp Ther 2013;344:696

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