(+)-MK 801 maleate

  ( 80 citations )    
Product Datasheet
Catalog Number:0924
Alternate Names:Dizocilpine
Chemical Name:(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate
Product Details
Citations (80)
Reviews
Biological Activity
A potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. An effective anti-ischemic agent in several animal models.

Available as part of the Mixed NMDA Receptor Tocriset™. (-)-enantiomer also available.

Technical Data
  • M.Wt:
    337.37
  • Formula:
    C16H15N.C4H4O4
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    77086-22-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (+)-MK 801 maleate include:

80 Citations: Showing 1 - 10
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  1. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
    Authors: Musella
    Sci Rep  2017;7(1):7363
  2. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons
    Authors: Philippart Et al.
    The Journal of Neuroscience  2016;6:7234
  3. Glutathione-Induced Calcium Shifts in Chick Retinal Glial Cells.
    Authors: Freitas Et al.
    PLoS One  2016;11:e0153677
  4. Altered neuronal excitability underlies impaired hippocampal function in an animal model of psychosis.
    Authors: Grüter Et al.
    J Biol Chem  2015;9:117
  5. α-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons.
    Authors: Velásquez-Martínez Et al.
    BMC Neurosci  2015;88:110
  6. Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
    Authors: Schitine Et al.
    PLoS One  2015;82:42
  7. Miro1 deficiency in amyotrophic lateral sclerosis.
    Authors: Zhang Et al.
    Cell Death Dis  2015;7:100
  8. Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
    Authors: Bertrand Et al.
    Cell Death Dis  2015;6:e1924
  9. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
    Authors: Birnbaum Et al.
    J Clin Invest  2015;6:e1791
  10. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    J Neurosci  2015;6:e1645
  11. Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system.
    Authors: Baxter Et al.
    Neuroscience  2015;6:6761
  12. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Int J Neuropsychopharmacol  2015;6:35458
  13. Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
    Authors: Stephen Et al.
    Front Behav Neurosci  2015;35:15996
  14. Rewarding Effects of Optical Stimulation of Ventral Tegmental Area Glutamatergic Neurons.
    Authors: Wang Et al.
    J Neurosci  2015;35:15948
  15. Oligodendrocytes Are Targets of HIV-1 Tat: NMDA and AMPA Receptor-Mediated Effects on Survival and Development.
    Authors: Zou Et al.
    J Neurosci  2015;35:11384
  16. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
    Authors: Wang Et al.
    Nat Commun  2015;290:168
  17. Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia.
    Authors: Quillinan Et al.
    Neuropharmacology  2015;284:555
  18. Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801.
    Authors: Kato Et al.
    Cell Death Dis  2015;15:222
  19. FTY720 attenuates excitotoxicity and neuroinflammation.
    Authors: Cipriani Et al.
    Curr Mol Med  2015;12:86
  20. Activity-dependent differences in function between proximal and distal Schaffer collaterals.
    Authors: Owen and Grover
    J Neurophysiol  2015;113:3646
  21. Decreased Expression of DREAM Promotes the Degeneration of Retinal Neurons.
    Authors: Chintala Et al.
    Front Aging Neurosci  2015;10:e0127776
  22. Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine.
    Authors: Parnaudeau Et al.
    Front Behav Neurosci  2014;8:35
  23. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    J Neurosci  2014;7:62
  24. β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network.
    Authors: Deléglise Et al.
    Acta Neuropathol Commun  2014;2:145
  25. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Neurochem Int  2014;17:1943
  26. Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
    Authors: Pan Et al.
    J Neuroinflammation  2014;124:4629
  27. NMDA-receptor activation but not ion flux is required for amyloid-β induced synaptic depression.
    Authors: Tamburri Et al.
    PLoS One  2013;8:e65350
  28. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
    Authors: Rojas Et al.
    Mol Pharmacol  2013;83:106
  29. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  30. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
    Authors: Koeglsperger Et al.
    Glia  2013;61:985
  31. Calcium responses to synaptically activated bursts of action potentials and their synapse-independent replay in cultured networks of hippocampal neurons.
    Authors: Bengtson Et al.
    Biochim Biophys Acta  2013;1833:1672
  32. Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons.
    Authors: Naka Et al.
    Pain  2013;154:1333
  33. Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation.
    Authors: Tsunekawa Et al.
    J Neuroinflammation  2013;14:4
  34. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
    Authors: Lundgaard Et al.
    PLoS Biol  2013;11:e1001743
  35. A modulatory effect of the feedback from higher visual areas to V1 in the mouse.
    Authors: Pasquale and Sherman
    J Neurophysiol  2013;109:2618
  36. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.
    Authors: Blouet and Schwartz
    PLoS One  2012;7:e51898
  37. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
    Authors: Klug Et al.
    PLoS One  2012;7:e45323
  38. Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.
    Authors: Pedrazzi Et al.
    PLoS One  2012;7:e44518
  39. Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
    Authors: Laricchiuta Et al.
    PLoS One  2012;7:e33260
  40. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
    Authors: Rodríguez-Muñoz Et al.
    Neuropsychopharmacology  2012;37:338
  41. State-dependent increase of cortical gamma activity during REM sleep after selective blockade of NR2B subunit containing NMDA receptors.
    Authors: Kocsis
    Sleep  2012;35:1011
  42. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
    Authors: Cassé Et al.
    J Neurosci  2012;32:5186
  43. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
    FASEB J  2012;32:3992
  44. Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability.
    Authors: Jarzylo and Man
    J Neurosci  2012;32:2552
  45. Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
    Authors: Peterfi Et al.
    J Neurosci  2012;32:14448
  46. Interleukin-1β causes anxiety by interacting with the endocannabinoid system.
    Authors: Rossi Et al.
    J Neurosci  2012;32:13896
  47. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci  2012;32:10767
  48. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
    Authors: Carlson Et al.
    Brain Behav  2012;2:391
  49. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res  2012;287:43
  50. Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
    Authors: Kim Et al.
    J Neurophysiol  2012;108:1965
  51. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097
  52. Pyramidal neurons are eurogenic hubs in the neurovascular coupling response to whisker stimulation.
    Authors: Lecrux Et al.
    J Neurosci  2011;31:9836
  53. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci  2011;14:866
  54. Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.
    Authors: Talpalar and Kiehn
    Front Neural Circuits  2010;4
  55. Suppression of the intrinsic apoptosis pathway by synaptic activity.
    Authors: Léveillé Et al.
    J Neurosci  2010;30:2623
  56. Rapid activation of dormant presynaptic terminals by phorbol esters.
    Authors: Chang Et al.
    J Neurosci  2010;30:10048
  57. Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex.
    Authors: Chao Et al.
    Cell Mol Life Sci  2009;66:1105
  58. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One  2009;4:e6011
  59. Mechanism of differential control of NMDA receptor activity by NR2 subunits.
    Authors: Gielen Et al.
    J Cereb Blood Flow Metab  2009;459:703
  60. Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death.
    Authors: Fallarini Et al.
    Br J Pharmacol  2009;157:1072
  61. Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway.
    Authors: Pais Et al.
    J Neurosci  2008;5:43
  62. Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
    Authors: Iwasato Et al.
    J Neurosci  2008;28:5931
  63. Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
    Authors: Léveillé Et al.
    FASEB J  2008;22:4258
  64. A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).
    Authors: Furness Et al.
    Neuroscience  2008;157:80
  65. Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice.
    Authors: Albright Et al.
    J Neurophysiol  2007;98:1610
  66. PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB [corrected] signaling.
    Authors: Chen Et al.
    J Neurophysiol  2007;98:1538
  67. Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
    Authors: Brager and Johnston
    J Neurosci  2007;27:13926
  68. A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction.
    Authors: Steward Et al.
    Learn Mem  2007;14:433
  69. Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells.
    Authors: Joo Et al.
    J Cell Sci  2007;120:1358
  70. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
    Authors: Shin Et al.
    J Cereb Blood Flow Metab  2006;26:1018
  71. Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: a novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency.
    Authors: Gerstner Et al.
    Pediatr Res  2005;57:771
  72. D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices.
    Authors: Shleper Et al.
    Nature  2005;25:9413
  73. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
    Authors: Calò Et al.
    J Neurosci  2005;25:2245
  74. Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.
    Authors: Tongiorgi Et al.
    J Neurosci  2004;24:6842
  75. 2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo.
    Authors: Liot Et al.
    Proc Natl Acad Sci U S A  2004;24:1153
  76. Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.
    Authors: Valable Et al.
    Oncotarget  2003;17:443
  77. Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.
    Authors: Gabriel Et al.
    FASEB J  2003;17:277
  78. Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa
    Authors: Chen Et al.
    J Virol  2002;76:9407
  79. Glutamate antagonists limit tumor growth.
    Authors: Rzeski Et al.
    J Neurosci  2001;98:6372
  80. Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus.
    Authors: Matthies Et al.
    Learn Mem  2000;7:227
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