A potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+
flux. An effective anti-ischemic agent in several animal models. Part of the Mixed NMDA Receptor Tocriset™
. (-)-MK 801 maleate
(Cat. No. 0955) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
The neuroprotective action of dizocilpine (MK-801) in the rat middle cerebral artery occlusion model of focal ischaemia.
Gill et al.
The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model.
Hatfield et al.
The anticonvulsant MK 801 is a potent N-methyl-D-aspartate antagonist.
Wong et al.
Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.
Zajaczkowski et al.
The citations listed below are publications that use Tocris products. Selected citations for (+)-MK 801 maleate include:
Showing Results 1 - 10 of 54