NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50
= 0.25 μ
M in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50
values are > 3 μ
M). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.
Gianni et al.
ACS Chem.Biol., 2010;5:981
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.
Drummond et al.
Nat.Rev.Drug Discov., 2011;10:453
The citations listed below are publications that use Tocris products. Selected citations for ML 171 include:
Showing Results 1 - 1 of 1