Catalog Number: 4653
Chemical Name: 2-Acetylphenothiazine
Biological Activity
NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50 = 0.25 μM in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50 values are > 3 μM). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
Technical Data
  • M.Wt:
    241.31
  • Formula:
    C14H11NOS
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    6631-94-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.
    Gianni et al.
    ACS Chem.Biol., 2010;5:981
  2. Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.
    Drummond et al.
    Nat.Rev.Drug Discov., 2011;10:453
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 171 include:

1 Citations: Showing 1 - 1

  1. Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine.
    Authors: Cheung Et al.
    Anal Bioanal Chem 2016;30:52

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