ML 171

  ( 2 citations )    
Product Datasheet
Catalog Number:4653
Chemical Name:2-Acetylphenothiazine
Product Details
Citations (2)
Reviews
Biological Activity
NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50 = 0.25 μM in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50 values are > 3 μM). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
Technical Data
  • M.Wt:
    241.31
  • Formula:
    C14H11NOS
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    6631-94-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 171 include:

2 Citations: Showing 1 - 2
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  1. Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics.
    Authors: Shen Et al.
    Oncotarget  2016;7:50596
  2. Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine.
    Authors: Cheung Et al.
    Anal Bioanal Chem  2016;30:52

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