ML 352 hydrochloride
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Description: High affinity and selective presynaptic choline transporter (CHT) inhibitor
Chemical Name: 4-Methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]benzamide hydrochloride
Purity: ≥98%
Biological Activity
High affinity and selective presynaptic choline transporter (CHT) inhibitor (Ki = 92 nM). Exhibits selectivity for CHT over dopamine, serotonin and noradrenalin transporters; acetylcholinesterase and cholineacetyltransferase; and a panel of 65 other GPCRs, ion channels and transporters.Technical Data
M.Wt:
423.93
Formula:
C21H29N3O4.HCl
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter.
Ennis et al.
ACS Chem.Neurosci., 2015;6:417 -
Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter.
Bollinger et al.
Bioorg.Med.Chem.Lett., 2015;25:1757
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