MM-22
Discontinued Product
Chemical Name: (3aS,4S,6aR)-Hexahydro-2-oxo-N-[2-[2-[2-[[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]amino]ethoxy]ethoxy]ethyl]-1H-thieno[3,4-d]imidazole-4-pentanamide
Purity: ≥98%
Biological Activity
Biotinylated anandamide analog; acts as a probe for visualizing the accumulation and intracellular trafficking of anandamide. Blocks anandamide uptake (IC50 = 0.5 μM in HaCaT cells); prevents interaction with FAAH, CB1 and TRPV1.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Evidence for the intracellular accumulation of anandamide in adiposomes.
Oddi et al.
Cell Mol.Life Sci., 2008;65:840 -
Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins.
Oddi et al.
Chem.Biol., 2009;16:624 -
Pitfalls and solutions in assaying anandamide transport in cells.
Oddi et al.
J.Lipid.Res., 2010;51:2435 -
Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation.
Fezza et al.
J.Lipid.Res., 2008;49:1216
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