Catalog Number: 2492
Alternate Names: NSC 631156
Chemical Name: 4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole
Biological Activity
Novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • Previously sold as Cat. No. 0564
Background References
  1. Rational design of novel immunosuppressive drugs: analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects.
    Crawford et al.
    J.Med.Chem., 1996;39:2690
  2. Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits.
    Al-Safi et al.
    Pol.J.Pharmacol., 2003;55:239
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