Novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro
= 2.7 μ
M) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
- Previously sold as Cat. No. 0564
Rational design of novel immunosuppressive drugs: analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects.
Crawford et al.
Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits.
Al-Safi et al.