Chemical Name: 4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole
Biological ActivityMNITMT is a novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.
Previously sold as Cat. No. 0564.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
- Previously sold as Cat. No. 0564
Rational design of novel immunosuppressive drugs: analogues of azathio. lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects.
Crawford et al.
Comparison of the effects of azathio. and its novel non-mercaptopurine analog on antibody response in rabbits.
Al-Safi et al.
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