Catalog Number: 2877
Chemical Name: 3,4-Methylenedioxy-β-nitrostyrene
Biological Activity
Selective inhibitor of Src and Syk tyrosine kinases. Inhibits thrombin-induced platelet aggregation via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism. Also inhibits inflammasome activation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor.
    Wang et al.
    Mol.Pharmacol., 2006;70:1380
  2. Synthesis and pharmacological evaluation of novel γ-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity.
    Wang et al.
    Biochem.Pharmacol., 2007;74:601
  3. 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.
    He et al.
    J.Biol.Chem., 2014;289:1142

Have you used MNS?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee


Customer Information