Moexipril hydrochloride
Chemical Name: 2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid hydrochloride
Purity: ≥99%
Biological Activity
Angiotensin-converting enzyme (ACE) inhibitor that is hydrolyzed in the liver to the active metabolite moexiprilat (IC50 values are 2.1 and 2700 nM for moexiprilat and moexipril respectively). Antihypertensive; decreases mean blood pressure in the spontaneous hypertensive rat (SHR). Also blocks degradation of bradykinin into inactive metabolites.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological and clinical profile of moexipril: a concise review.
Chrysant and Chrysant
J.Clin.Pharmacol., 2004;44:827 -
Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enal.
Edling et al.
J.Pharmacol.Exp.Ther., 1995;275:854 -
Pharmacological and toxicological studies of the new angiotensin converting enzyme inhibitor moex. hydrochloride.
Friehe and Ney
Arzneim.-Forsch., 1997;47:132
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