Catalog Number: 1305
Chemical Name: 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
Biological Activity
Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Harvard University
Background References
  1. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.
    Kapoor et al.
    J.Cell Biol., 2000;150:975
  2. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
    Mayer et al.
    Science, 1999;286:971

The citations listed below are publications that use Tocris products. Selected citations for Monastrol include:

Showing Results 1 - 10 of 10

  1. C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle.
    Authors: Floriot Et al.
    Cell Cycle
  2. A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly.
    Authors: Barr and Bakal
    Nat Commun
  3. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.
    Authors: Kabeche and Compton
    J Biol Chem
  4. p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.
    Authors: Habu and Matsumoto
  5. Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.
    Authors: Shrestha and Draviam
    Curr Biol
  6. Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance.
    Authors: Corrigan Et al.
  7. High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.
    Authors: Lera and Burkard
    J Biol Chem
  8. Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors.
    Authors: Bassett Et al.
    Sci Rep
  9. Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.
    Authors: Samoshkin Et al.
    PLoS One
  10. Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle.
    Authors: Trinkle-Mulcahy Et al.
    Mol Biol Cell
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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