Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50
= 14 μ
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Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.
Kapoor et al.
J.Cell Biol., 2000;150:975
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
Mayer et al.
The citations listed below are publications that use Tocris products. Selected citations for Monastrol include:
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