Sodium ionophore. Neutralizes acidic intracellular compartments. Disrupts Golgi apparatus structure and inhibits vesicular transport in eukaryotic cells. Induces apoptosis in prostate cancer cells. Antiprotozoal, antibacterial and antifungal agent.
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All Tocris products are intended for laboratory research use only.
Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells.
Ketola et al.
Mol.Cancer Ther., 2010;9:3175
Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity.
Mollenhauer et al.
Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.
Łowicki and Huczyński