Catalog Number: 5223
Chemical Name: 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-Dioxaspiro[4.5]decane-7-butyric acid sodium salt
Biological Activity
Sodium ionophore. Neutralizes acidic intracellular compartments. Disrupts Golgi apparatus structure and inhibits vesicular transport in eukaryotic cells. Induces apoptosis in prostate cancer cells. Antiprotozoal, antibacterial and antifungal agent.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells.
    Ketola et al.
    Mol.Cancer Ther., 2010;9:3175
  2. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity.
    Mollenhauer et al.
    Biochim.Biophys.Acta, 1990;1031:225
  3. Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.
    &#0321owicki and Huczy&#324ski
    Biomed.Res.Int, 2013;2013
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