Monensin sodium salt
Chemical Name: 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-Dioxaspiro[4.5]decane-7-butyric acid sodium salt
Biological ActivitySodium ionophore. Neutralizes acidic intracellular compartments. Disrupts Golgi apparatus structure and inhibits vesicular transport in eukaryotic cells. Induces apoptosis in prostate cancer cells. Antiprotozoal, antibacterial and antifungal agent.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity.
Mollenhauer et al.
Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.
Łowicki and Huczyński
Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells.
Ketola et al.
Mol.Cancer Ther., 2010;9:3175
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