Catalog Number: 5223
Chemical Name: 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-Dioxaspiro[4.5]decane-7-butyric acid sodium salt
Biological Activity
Sodium ionophore. Neutralizes acidic intracellular compartments. Disrupts Golgi apparatus structure and inhibits vesicular transport in eukaryotic cells. Induces apoptosis in prostate cancer cells. Antiprotozoal, antibacterial and antifungal agent.
Technical Data
  • M.Wt:
    692.85
  • Formula:
    C36H61NaO11
  • Solubility:
    Soluble to 100 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
    22373-78-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells.
    Ketola et al.
    Mol.Cancer Ther., 2010;9:3175
  2. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity.
    Mollenhauer et al.
    Biochim.Biophys.Acta, 1990;1031:225
  3. Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.
    &#0321owicki and Huczy&#324ski
    Biomed.Res.Int, 2013;2013

Have you used Monensin sodium salt?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information