Mouse beta ‑Actin Alexa Fluor™ Plus 647‑conjugated Antibody

Name: Mouse beta ‑Actin Alexa Fluor™ Plus 647‑conjugated Antibody
Brand: R&D Systems
SKU: FAB11702AFP647
Price: 559 USD
Availability: InStock

R&D Systems | Catalog # FAB11702AFP647

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Product Specifications
Applications
Background
Product Documents
Specific Notices
Research Areas
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Key Product Details

Species Reactivity

Mouse

Applications

Immunohistochemistry, Western Blot, Immunocytochemistry

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Monoclonal Rat IgG_2A Clone # 1104805

View all beta-Actin Primary Antibodies »

Product Specifications

Specificity

Detects a synthetic peptide specific for mouse beta-actin around amino acid 50 in Direct ELISA.

Clonality

Monoclonal

Host

Rat

Isotype

IgG_2A

Applications for Mouse beta ‑Actin Alexa Fluor™ Plus 647‑conjugated Antibody

Application

Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: beta-Actin

Beta actin (ACTB) is a canonical member of the actin family of proteins, with a molecular weight of approximately 42 kDa. Actins are highly conserved proteins that play pivotal roles in various cellular processes, including the maintenance of the cytoskeleton and cell motility, division, and signaling. ACTB is ubiquitously expressed in all eukaryotic cells and is crucial for structural integrity and motility. It is involved in essential biological processes such as cellular trafficking and the maintenance of cell shape and polarity. Dysregulation of ACTB expression or function can lead to notable pathologies, including cancer progression, where it is implicated in tumor cell migration, invasion, and metastasis. Mutations in the ACTB gene are also associated with developmental disorders and conditions like Baraitser-Winter syndrome. Additionally, ACTB plays a critical role in intracellular transport processes and the functioning of the actin cytoskeleton, highlighting its potential as a biomarker for various diseases and a target for therapeutic interventions.

References

Pollard, T. D., & Cooper, J. A. (2009). Actin, a central player in cell shape and movement. Science, 326(5957), 1208-1212. doi: 10.1126/science.1175862.
Perrin, B. J., & Ervasti, J. M. (2010). The actin gene family: Function follows isoform. Cytoskeleton, 67(10), 630-634. doi: 10.1002/cm.20475.
Jones, S. L., Korobova, F., Svitkina, T. (2019). Origin of the actin cytoskeleton. Nature Reviews Molecular Cell Biology, 20(11), 675-689. doi: 10.1038/s41580-019-0164-5.

Alternate Names

ACTB, betaActin

Entrez Gene IDs

60 (Human); 11461 (Mouse); 81822 (Rat)

Gene Symbol

ACTB

UniProt

P60710 (Mouse)

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Product Specific Notices for Mouse beta ‑Actin Alexa Fluor™ Plus 647‑conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only