Mouse CCL2/JE/MCP-1 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CCL2/JE/MCP-1

Mouse CCL2 is a member of the beta (C-C) subfamily of chemokines. The murine CCL2 gene was initially identified as a platelet-derived growth factor-inducible gene in murine fibroblasts. Mouse CCL2 cDNA encodes a 148 amino acid (aa) residue with a putative 23 aa signal peptide that is cleaved to generate the mature protein. Mouse CCL2 shares 82% amino acid sequence identity with rat CCL2. Mouse CCL2 also shares 55% amino acid sequence identity with human MCP-1. Compared to human MCP-1, mouse CCL2 has a 49 aa residue extension at the carboxy-terminus. Mouse CCL2 has full activity on human cells while human MCP-1 has limited activity on mouse cells.

Product Datasheets

Related Research Areas

• Alpha Granule Soluble Molecules
• CC Chemokines and Receptors
• Chemokines and Receptors
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Angiogenesis
• gamma delta T Cells
• HIF Transcription Factors
• Inflammatory Mediators
• Macrophage Activation Markers
• Microglia Activation Markers
• Microglia Development
• Molecules Secreted by VSMC
• Neuroinflammatory Factors
• Uptake of Amyloid beta by Macrophages