Mouse DC-SIGN/CD209 Alexa Fluor® 647-conjugated Antibody
Mouse DC-SIGN/CD209 Alexa Fluor® 647-conjugated Antibody Summary
Accession # Q91ZX1
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Mouse Dendritic Cell-specific ICAM-3 Grabbing Non-integrin (DC-SIGN)/CD209, also known as CD209 Antigen-like Protein A, is a member of the C-type lectin family (1). Mouse DC-SIGN/CD209 is a 33 kDa, 238 amino acid (aa) type II transmembrane protein (2). The extracellular region contains a Ca2+-dependent carbohydrate-binding lectin domain (2). In addition to the full-length mouse DC-SIGN/CD209, a second, truncated splice variant has been reported. DC-SIGN/CD209 is not well conserved between mouse and human with the extracellular domain sharing only 63% aa identity. The DC-SIGN/CD209 lectin domain binds mannose oligosaccharides on pathogens including HIV as well as self glycoproteins including ICAMs (2-4). DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation (2, 5, 6).
- Liu, W. et al. (2004) J. Biol. Chem. 279:18748.
- Caminschi, I. et al. (2001) Mol. Immunol. 38:365.
- Curtis, B.M. et al. (1992) Proc. Natl. Acad. Sci. USA 89:8356.
- Anthony, R.M. et al. (2008) Proc. Natl. Acad. Sci. USA 105:19571.
- Geijtenbeek, T.B. et al. (2000) Cell 100:575.
- Garcia-Vallejo, J.J. and Y. van Kooyk (2013) Trends Immunol. 34:482.
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