Mouse Frizzled-3 (NP_067433) VersaClone cDNA

Catalog # Availability Size / Price Qty
R&D Systems VersaClone cDNA Plasmids
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Product Details

Mouse Frizzled-3 (NP_067433) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: Frizzled-3

This group of G protein-coupled receptors consists of 10 structurally-related, seven transmembrane proteins with a divergent N-terminal signal peptide and a variable-length C-terminal tail. The Frizzled family proteins contain a highly conserved cysteine-rich domain and a variable length linker region. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Planar Cell Polarity and Wnt/Ca2+ Pathways). Wnt/Frizzled signaling is involved in a variety of developmental processes including cell fate determination, cell polarity, tissue patterning, and control of cell proliferation. Activation of a given Wnt/Frizzled signaling cascade is dependent on the Wnt ligand and the cell context. Frizzled proteins also form co-receptor complexes with LRP, ROR, and Ryk molecules.

Entrez Gene IDs
7976 (Human); 14365 (Mouse)
Alternate Names
frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); Frizzled3; Frizzled-3; Fz-3; FZD3; hFz3


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