Mouse IGSF9B Antibody Summary
Accession # Q05BQ1
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of IGSF9 in HEK293 Human Cell Line Transfected with Mouse IGSF9 and eGFP by Flow Cytometry. HEK293 human cell line transfected with (A) Mouse IGSF9 or (B) irrelevant protein, and eGFP was stained with Rat Anti-Mouse IGSF9 Monoclonal Antibody (Catalog # MAB9140) followed by APC-conjugated Goat anti-Rat IgG Secondary Antibody (Catalog # F0113). Quadrant markers were set based on Rat IgG2B Isotype Control Antibody (Catalog # MAB0061). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
IGSF9, also known as Dasm1, is an approximately 130 kDa transmembrane protein that plays a role in neuronal synapse maintenance and function (1). Mature mouse Dasm1 consists of a 714 amino acid (aa) extracellular domain (ECD) with 5 Ig-like domains and 2 fibronectin type-3 domains, a 21 aa transmembrane segment, and a 424 aa cytoplasmic domain (2). Within the ECD, mouse Dasm1 shares 90% and 96% aa sequence identity with human and rat Dasm1, respectively. Alternative splicing generates an additional isoform that is truncated following the fifth Ig-like domain. Dasm1 is expressed in the dorsal root and trigeminal ganglia, forebrain, cortex, dentate gyrus, pyramidal cells, Purkinje cells, and hippocampal CA1 interneurons (2-5). It localizes to dendrites, cell bodies, and post-synaptic densities (3, 6). Dasm1 functions as a homophilic adhesion protein that supports the maintenance of inhibitory synapses as well as inhibitory neurotransmission (5, 6).
- Hansen, M. and P.S. Walmod (2013) Neurochem. Res. 38:1236.
- Doudney, K. et al. (2002) Genomics 79:663.
- Shi, S.-H. et al. (2004) Proc. Natl. Acad. Sci. USA 101:13341.
- Mishra, A. et al. (2008) Mol. Cell. Biol. 28:2782.
- Mishra, A. et al. (2014) J. Neurosci. 34:4187.
- Shi, S.-H. et al. (2004) Proc. Natl. Acad. Sci. USA 101:13346.
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