Mouse IL-15R alpha Biotinylated Antibody
Mouse IL-15R alpha Biotinylated Antibody Summary
Gly33-Lys205
Accession # Q60819
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-15R alpha
Interleukin 15 receptor alpha (IL-15 R alpha ) is a high affinity receptor that specifically binds IL-15 with high affinity and associates as a heterotrimer with the IL-2 receptors beta and gamma subunits to initiate signal transduction. IL-15 R alpha is expressed on a wide variety of T cells and B cells as well as non-lymphoid cells. IL‑15 R alpha is a 58-60 kDa protein that shares structural similarities to the IL-2 R alpha protein. IL-15 R alpha and IL-2 R alpha genes also share similar intron-exon organization and are closely linked on human chromosome 10p14-p15. Human IL-15 R alpha shares 45% amino acid (aa) homology with the mouse form of the receptor. Signaling of IL‑15 can occur in one of three ways; through the heterotrimeric complex of IL-15 R alpha, IL-2 R beta, and IL-2 R gamma c, through the heterodimeric complex of IL-2 receptors beta and gamma common, through a novel 60-65 kDa IL-15 RX subunit found on mast cells. The binding of IL-15 to IL-15 R alpha has been reported to antagonize the TNF‑ alpha -mediated apoptosis in fibroblasts by competing with TNF RI for TRAF2 binding.
- Anderson, D.M. et al. (1995) J. Biol. Chem. 270:29862.
- Bulfone-Paus, S. et al. (1999) FASEB 13:1575.
- Waldemann, T.A. and Y. Tagaya (1999) Ann. Rev. Immunol. 17:19.
- Dubois, S. et al. (1999) J. Biol. Chem. 274:26978.
Product Datasheets
Citations for Mouse IL-15R alpha Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
16
Citations: Showing 1 - 10
Filter your results:
Filter by:
-
NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity
Authors: N Simonovi?, A Witalisz-S, K Meissl, C Lassnig, U Reichart, T Kolbe, M Farlik, C Bock, V Sexl, M Müller, B Strobl
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia
Cell Biosci, 2016;6(0):30.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-15 receptor alpha signaling constrains the development of IL-17-producing gammadelta T cells.
Authors: Colpitts S, Puddington L, Lefrancois L
Proc Natl Acad Sci U S A, 2015;112(31):9692-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Different NK cell developmental events require different levels of IL-15 trans-presentation.
Authors: Lee GA, Liou YH, Wang SW, Ko KL, Jiang ST, Liao NS
J. Immunol., 2011;187(3):1212-21.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R alpha.
Authors: Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y
Blood, 2011;117(15):4032-40.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.
Authors: Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW
J. Immunol., 2009;182(12):7398-407.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer.
Authors: Zhang M, Yao Z, Dubois S, Ju W, Muller JR, Waldmann TA
Proc. Natl. Acad. Sci. U.S.A., 2009;106(18):7513-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.
Authors: Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA
J. Immunol., 2008;181(5):3285-90.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Antigen controls IL-7Ralpha expression levels on CD8 T cells during full activation or tolerance induction.
Authors: Hammerbeck CD, Mescher MF
J. Immunol., 2008;180(4):2107-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Functional Assay -
A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction.
Authors: Sabatos CA, Doh J, Chakravarti S, Friedman RS, Pandurangi PG, Tooley AJ, Krummel MF
Immunity, 2008;29(2):238-48.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.
Authors: Rowley J, Monie A, Hung CF, Wu TC
J. Immunol., 2008;181(12):8237-47.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8 alpha alpha+ IELs in the intestine.
Authors: Lai YG, Hou MS, Hsu YW, Chang CL, Liou YH, Tsai MH, Lee F, Liao NS
J. Immunol., 2008;180(6):3757-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells.
Authors: Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L
J. Immunol., 2008;180(7):4679-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Authors: Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA, Surh CD, Goldrath AW
Blood, 2008;112(9):3704-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.
Authors: French AR, Sjolin H, Kim S, Koka R, Yang L, Young DA, Cerboni C, Tomasello E, Ma A, Vivier E, Karre K, Yokoyama WM
J. Immunol., 2006;177(8):4981-90.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-gamma synthesis.
Authors: Gould MP, Greene JA, Bhoj V, DeVecchio JL, Heinzel FP
J. Immunol., 2004;172(3):1754-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsIsotype Controls
Reconstitution Buffers
Staining Reagents
Supplemental Cell Selection Products
Supplemental ELISA Products
Reviews for Mouse IL-15R alpha Biotinylated Antibody
There are currently no reviews for this product. Be the first to review Mouse IL-15R alpha Biotinylated Antibody and earn rewards!
Have you used Mouse IL-15R alpha Biotinylated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
