Mouse MARCO APC-conjugated Antibody Summary
Gln70-Ser518
Accession # Q60754
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of MARCO in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse MARCO APC-conjugated Monoclonal Antibody (Catalog # FAB2956A, filled histogram) or isotype control antibody (Catalog # IC005A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of MARCO in J774 Mouse Cell Line by Flow Cytometry. J774 mouse monocyte-macrophage cell line, resting (open histogram), or treated with 500 ng/ml LPS for 3 days (filled histogram) were stained with Rat Anti-Mouse MARCO APC-conjugated Monoclonal Antibody (Catalog # FAB2956A). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: MARCO
Mouse MARCO is a type II transmembrane glycoprotein belonging to the class A scavenger receptor family. It is constitutively expressed in subsets of macrophages found in the marginal zone of the spleen, the peritoneum, and the medullary cord of lymph nodes. The extracellular domains of MARCO form a 220 kDa disulfide-linked homotrimer on the cell surface. MARCO binds both gram positive and gram negative bacteria, as well as oxidized low-density lipoprotein. The amino acid sequence of mouse MARCO extracellular domain is 69% identical to that of human MARCO.
Product Datasheets
Citations for Mouse MARCO APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes
Authors: X Wu, KK Dayanand, RP Thylur, CC Norbury, DC Gowda
J. Biol. Chem., 2017-07-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Phagosomal Acidification Prevents Macrophage Inflammatory Cytokine Production to Malaria, and Dendritic Cells Are the Major Source at the Early Stages of Infection: IMPLICATION FOR MALARIA PROTECTIVE IMMUNITY DEVELOPMENT.
Authors: Wu X, Gowda N, Gowda D
J Biol Chem, 2015-08-03;290(38):23135-47.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
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Reviews for Mouse MARCO APC-conjugated Antibody
Average Rating: 4 (Based on 1 Review)
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Binds really nicely to muMarco transiently expressing cells, does not bind to untransfected cells.
