Mouse Thrombopoietin R/Tpo R Biotinylated Antibody

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Product Details
Citations (1)
Supplemental Products

Mouse Thrombopoietin R/Tpo R Biotinylated Antibody Summary

Species Reactivity
Detects mouse Thrombopoietin R/Tpo R in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human Tpo R and recombinant mouse Epo R is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse Thrombopoietin R/Tpo R
Accession # CAA52031
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse Thrombopoietin R/Tpo R Fc Chimera (Catalog # 1317-TR)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Thrombopoietin R/Tpo R

Thrombopoietin receptor (Tpo R), also known as myeloproliferative leukemia protein (c-mpl), is a type I membrane protein that is a member of the hematopoietin/cytokine receptor superfamily. Thrombopoietin (Tpo) is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitro and in vivo. Receptor dimerization occurs upon ligand binding. Downstream signaling cascades utilize the Ras/MAP and JAK/STAT pathways (1). In humans, variations at the 3’ end on the molecule result in the formation of 3 distinct mRNA species, a P-form, a K-form, and a potentially secreted form. The predominant form in humans is the P-form, which encodes a full length receptor. In mouse, mRNA for a full length form, a potentially secreted form, and a form lacking 8 amino acids in the extra-cytoplasmic domain has been detected (2). The human and mouse receptors share approximately 81% amino acid identity. Tpo R is expressed at low levels in various cell types including hematopoietic progenitor cells, megakaryocytes and platelets.

  1. Kuter, D.J. and J. Li (2001) in Cytokine Reference, p. 1953. Oppenhiem, J.J. and M. Feldmann eds. Academic Press.
  2. Kaushansky, K. and J.G. Drachman (2002) Oncogene 21:3359.
Long Name
Thrombopoietin Receptor
Entrez Gene IDs
4352 (Human); 17480 (Mouse)
Alternate Names
CD110 antigen; CD110; c-Mpl; MPL; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; Thrombopoietin R; thrombopoietin receptor; TpoR; TPO-R; TPORMPLV

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Citation for Mouse Thrombopoietin R/Tpo R Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Transcriptional regulation of bone marrow thrombopoietin by platelet proteins.
    Authors: McIntosh B, Kaushansky K
    Exp. Hematol., 2008-04-14;36(7):799-806.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Immunoprecipitation


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