MPC 6827 hydrochloride
Chemical Name: N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
Purity: ≥98%
Biological Activity
MPC 6827 hydrochloride is a potent inhibitor of microtubule formation (IC50 = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels.
Mahal et al.
ChemMedChem., 2014;9:847 -
MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.
Kasibhatla et al.
Cancer Res., 2007;67:5865 -
Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration.
Sirisoma et al.
J.Med.Chem., 2009;52:2341
Product Datasheets
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Citations for MPC 6827 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for MPC 6827 hydrochloride include:
2 Citations: Showing 1 - 2
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Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse.
Authors: Christopher T Et al.
Front Med (Lausanne) 2022;9:817274
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Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model.
Authors: Suzanne Et al.
EJNMMI Res 2022;12:41
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