MRS 1845
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylic acid ethyl, methyl ester
Purity: ≥98%
Biological Activity
Potent blocker of store-operated Ca2+ channels; inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
Szikra et al.
PLoS ONE, 2009;4:e6723 -
Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors.
Szikra et al.
J.Physiol., 2008;586:4859 -
Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells.
Harper et al.
Biochem.Pharmacol., 2003;65:329
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Citation for MRS 1845
The citations listed below are publications that use Tocris products. Selected citations for MRS 1845 include:
1 Citation: Showing 1 - 1
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GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
Authors: Berlinguer-Palmini Et al.
PLoS One 2013;8:e82180
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