Catalog Number: 1866
Alternate Names: N-Propylargylnitrendipine
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylic acid ethyl, methyl ester
Biological Activity
Potent blocker of store-operated Ca2+ channels; inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol with gentle warming and to 10 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells.
    Harper et al.
    Biochem.Pharmacol., 2003;65:329
  2. Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels.
    Szikra et al.
    PLoS ONE, 2009;4:e6723
  3. Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors.
    Szikra et al.
    J.Physiol., 2008;586:4859

The citations listed below are publications that use Tocris products. Selected citations for MRS 1845 include:

Showing Results 1 - 1 of 1

  1. GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
    Authors: Berlinguer-Palmini Et al.
    PLoS One
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