Catalog Number: 0900
Chemical Name: 2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt
Biological Activity
A competitive antagonist at P2Y1 receptors (KB = 100 nM). Selective over P2X1 (IC50 = 1.15 μM), P2X3 (IC50 = 12.9 μM), P2X2, P2X4, P2Y2, P2Y4 and P2Y6 receptors. Inhibits the upregulation of NTPDase1 by ATPγS.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the NIH, US Patent 60/029,855
Background References
  1. Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells.
    Lu et al.
    J.Pharmacol.Exp.Ther., 2007;323:157
  2. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands.
    Nandanan et al.
    J.Med.Chem., 2000;43:829
  3. Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.
    Boyer et al.
    Br.J.Pharmacol., 1998;124:1
  4. Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors.
    Brown et al.
    Drug Dev.Res., 2000;49:253

The citations listed below are publications that use Tocris products. Selected citations for MRS 2179 tetrasodium salt include:

Showing Results 1 - 10 of 26

  1. Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation.
    Authors: Riquelme Et al.
    J Neurosci
  2. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One
  3. Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.
    Authors: Giachini Et al.
    PLoS One
  4. Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.
    Authors: Wang Et al.
    PLoS One
  5. Lactate-mediated glia-neuronal signalling in the mammalian brain.
    Authors: Tang Et al.
    Nat Commun
  6. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
    Authors: Ashpole Et al.
    J Biol Chem
  7. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum.
    Authors: Fei Et al.
    Br J Pharmacol
  8. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate.
    Authors: Alefishat Et al.
    Br J Pharmacol
  9. Pharmacodynamic interplay of the P2Y(1), P2Y(12), and TxA(2) pathways in platelets: the potential of triple antiplatelet therapy with P2Y(1) receptor antagonism.
    Authors: Oestreich Et al.
    Thromb Res
  10. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal
  11. Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes.
    Authors: Balduini Et al.
  12. Changes in neuromuscular transmission in the W/W(v) mouse internal anal sphincter.
    Authors: Duffy Et al.
    Neurogastroenterol Motil
  13. Purinergic receptors are required for HIV-1 infection of primary human macrophages.
    Authors: Hazleton Et al.
    J Immunol
  14. Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits.
    Authors: Martín-Gil Et al.
    Br J Pharmacol
  15. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.
    Authors: Puerto Et al.
    J Cell Sci
  16. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.
    Authors: Begum Et al.
    J Neurochem
  17. Multiscale prediction of patient-specific platelet function under flow.
    Authors: Flamm Et al.
  18. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
    Authors: Tran Et al.
    Assay Drug Dev Technol
  19. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.
    Authors: Kuboyama Et al.
    Front Cell Dev Biol
  20. β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons.
    Authors: Hwang Et al.
  21. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.
    Authors: Huang Et al.
    Cancer Med
  22. Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons.
    Authors: Li and Olson
    Am J Physiol Cell Physiol
  23. Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y (12) receptor and is correlated with protein expression of P2Y (12).
    Authors: Braun Et al.
    Purinergic Signal
  24. Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle.
    Authors: Mutafova-Yambolieva Et al.
    Proc Natl Acad Sci U S A
  25. PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.
    Authors: Holinstat Et al.
    J Biol Chem
  26. Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells.
    Authors: Czajkowski Et al.
    Br J Pharmacol
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