MRS 2179 tetrasodium salt

  ( 31 citations )    
Product Datasheet
Catalog Number:0900
Chemical Name:2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt
Product Details
Citations (31)
Supplemental Products
Reviews
Biological Activity
A competitive antagonist at P2Y1 receptors (KB = 100 nM). Selective over P2X1 (IC50 = 1.15 μM), P2X3 (IC50 = 12.9 μM), P2X2, P2X4, P2Y2, P2Y4 and P2Y6 receptors. Inhibits the upregulation of NTPDase1 by ATPγS.
Technical Data
  • M.Wt:
    513.16
  • Formula:
    C11H13N5O9P2Na4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    1454889-37-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the NIH, US Patent 60/029,855
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MRS 2179 tetrasodium salt include:

31 Citations: Showing 1 - 10
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  1. A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y12 receptor in platelets.
    Authors: Makkawi
    Thromb Res  2017;161:12
  2. Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X1, P2X2, P2X3 channels, P2Y and A3 metabotropic receptors in neurotransmission.
    Authors: Liñán-Rico Et al.
    Neuropharmacology  2015;95:83
  3. Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation.
    Authors: Riquelme Et al.
    J Neurosci  2015;3:25
  4. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors.
    Authors: Kawano Et al.
    PLoS One  2015;10:e0127919
  5. Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.
    Authors: Giachini Et al.
    PLoS One  2014;9:e91890
  6. Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.
    Authors: Wang Et al.
    PLoS One  2014;9:e110101
  7. Lactate-mediated glia-neuronal signalling in the mammalian brain.
    Authors: Tang Et al.
    Nat Commun  2014;5:3284
  8. Detection of platelet sensitivity to inhibitors of COX-1, P2Y1, and P2Y12 using a whole blood microfluidic flow assay.
    Authors: Li and Diamond
    Thromb Res  2014;133:203
  9. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
    Authors: Ashpole Et al.
    J Biol Chem  2013;288:14599
  10. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum.
    Authors: Fei Et al.
    Br J Pharmacol  2013;168:880
  11. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate.
    Authors: Alefishat Et al.
    Br J Pharmacol  2013;168:1911
  12. Pharmacodynamic interplay of the P2Y(1), P2Y(12), and TxA(2) pathways in platelets: the potential of triple antiplatelet therapy with P2Y(1) receptor antagonism.
    Authors: Oestreich Et al.
    Thromb Res  2013;131:e64
  13. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal  2013;11:70
  14. Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries.
    Authors: Alsaqati Et al.
    Purinergic Signal  2013;10:241
  15. Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes.
    Authors: Balduini Et al.
    Haematologica  2012;97:1657
  16. Changes in neuromuscular transmission in the W/W(v) mouse internal anal sphincter.
    Authors: Duffy Et al.
    Neurogastroenterol Motil  2012;24:e41
  17. Purinergic receptors are required for HIV-1 infection of primary human macrophages.
    Authors: Hazleton Et al.
    J Immunol  2012;188:4488
  18. Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits.
    Authors: Martín-Gil Et al.
    Br J Pharmacol  2012;165:1163
  19. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.
    Authors: Puerto Et al.
    J Cell Sci  2012;125:176
  20. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.
    Authors: Begum Et al.
    J Neurochem  2012;120:622
  21. Multiscale prediction of patient-specific platelet function under flow.
    Authors: Flamm Et al.
    Blood  2012;120:190
  22. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.
    Authors: Tran Et al.
    Assay Drug Dev Technol  2012;10:37
  23. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.
    Authors: Kuboyama Et al.
    Front Cell Dev Biol  2011;31:1930
  24. β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons.
    Authors: Hwang Et al.
    Gastroenterology  2011;140:608
  25. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds.
    Authors: Huang Et al.
    Cancer Med  2009;29:13909
  26. Purinergic and nitrergic junction potential in the human colon.
    Authors: Gallego Et al.
    Am J Physiol Gastrointest Liver Physiol  2008;295:G522
  27. Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons.
    Authors: Li and Olson
    Am J Physiol Cell Physiol  2008;295:C1550
  28. Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y (12) receptor and is correlated with protein expression of P2Y (12).
    Authors: Braun Et al.
    Purinergic Signal  2007;3:195
  29. Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle.
    Authors: Mutafova-Yambolieva Et al.
    Proc Natl Acad Sci U S A  2007;104:16359
  30. PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.
    Authors: Holinstat Et al.
    J Biol Chem  2006;281:26665
  31. Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells.
    Authors: Czajkowski Et al.
    Br J Pharmacol  2004;141:497
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