A competitive antagonist at P2Y1
= 100 nM). Selective over P2X1
= 1.15 μ
= 12.9 μ
receptors. Inhibits the upregulation of NTPDase1 by ATPγ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from the NIH, US Patent 60/029,855
Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells.
Lu et al.
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands.
Nandanan et al.
Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.
Boyer et al.
Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors.
Brown et al.
Drug Dev.Res., 2000;49:253
The citations listed below are publications that use Tocris products. Selected citations for MRS 2179 tetrasodium salt include:
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