A competitive antagonist at P2Y
= 100 nM). Selective over P2X
receptors. Inhibits the upregulation of NTPDase1 by ATP
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from the NIH, US Patent 60/029,855
Stimulation of the P2Y 1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells.
Lu et al.
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y 1 receptor ligands.
Nandanan et al.
Competitive and selective antagonism of P2Y 1 receptors by N 6-methyl 2'-deoxyadenosine 3',5'-bisphosphate.
Boyer et al.
Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors.
Brown et al.
Drug Dev.Res., 2000;49:253
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